Benzoic Acid‐Promoted Intermolecular [3+2] Cycloaddition with Air as the Terminal Oxidant: General Approach toward Pyrrolo[2, 1‐ a ]isoquinolines | Zendy

Zheng Kailu | Zendy; Zhuang Shiyi | Zendy; You Minqi | Zendy; Shu Wenming | Zendy; Wu Anxin | Zendy; Wu Yandong | Zendy

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Benzoic Acid‐Promoted Intermolecular [3+2] Cycloaddition with Air as the Terminal Oxidant: General Approach toward Pyrrolo[2, 1‐ a ]isoquinolines

Author(s) -

Zheng Kailu,

Zhuang Shiyi,

You Minqi,

Shu Wenming,

Wu Anxin,

Wu Yandong

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201702044

Subject(s) - cycloaddition , intermolecular force , benzoic acid , chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , molecule , catalysis

A novel benzoic acid‐promoted intermolecular 1,3‐dipolar cycloaddition reaction has been developed for the one‐pot construction of biologically important pyrrolo[2, 1‐ a ]isoquinolines. This metal‐free reaction between dipolarophiles and in situ‐generated azomethine ylides avoids the pre‐preparation of N‐substituted substrates and allows for the efficient formation of one C−N bond and two C−C bonds.

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