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Benzoic Acid‐Promoted Intermolecular [3+2] Cycloaddition with Air as the Terminal Oxidant: General Approach toward Pyrrolo[2, 1‐ a ]isoquinolines
Author(s) -
Zheng Kailu,
Zhuang Shiyi,
You Minqi,
Shu Wenming,
Wu Anxin,
Wu Yandong
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702044
Subject(s) - cycloaddition , intermolecular force , benzoic acid , chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , molecule , catalysis
A novel benzoic acid‐promoted intermolecular 1,3‐dipolar cycloaddition reaction has been developed for the one‐pot construction of biologically important pyrrolo[2, 1‐ a ]isoquinolines. This metal‐free reaction between dipolarophiles and in situ‐generated azomethine ylides avoids the pre‐preparation of N‐substituted substrates and allows for the efficient formation of one C−N bond and two C−C bonds.