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Glycerol: A Promising Benign Solvent for Catalyst Free One‐Pot Multi‐Component Synthesis of Pyrano[2,3‐c]pyrazoles and Tetrahydro‐benzo[b]pyrans at Ambient Temperature
Author(s) -
Abdel Hamid Afaf,
AbdElmonem Mohamed,
Hayallah Alaa M.,
Abo Elsoud Fatma A.,
Sadek Kamal U.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702011
Subject(s) - malononitrile , hydrazine (antidepressant) , atom economy , catalysis , chemistry , glycerol , solvent , aryl , hydrate , organic chemistry , chromatography , alkyl
A simple and efficient synthesis of 6‐amino‐5‐cyano‐4‐aryl‐1,4‐dihydropyrano[2, 3‐c]pyrazoles and 2‐amino‐3‐cyano‐4‐aryl‐7,7‐dimethyl‐5,6,7,8‐tetrahydrobenzo[b]pyrans has been developed that involves a four‐component reaction of aromatic aldehydes, malononitrile, hydrazine hydrate or phenyl hydrazine and 1,3‐dicarbonyl compounds using glycerol as both solvent and catalyst at ambient temperature. Several advantages have been achieved such as high yields, facile conducting reactants or working up products, high Eco Scale, atom economy and the absence of toxic or hazardous catalysts or solvents.