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Fe(III)‐Exchanged Montmorillonite as Reusable Heterogeneous Protonic Acid Catalyst for Michael Addition of Indole in Water
Author(s) -
Matsuzawa Ryosuke,
Nishimura Shun,
Ebitani Kohki
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701959
Subject(s) - indole test , montmorillonite , michael reaction , catalysis , chemistry , aldehyde , acetal , ketone , solid acid , medicinal chemistry , organic chemistry , polymer chemistry , nuclear chemistry
Fe 3+ ‐exchanged montmorillonite (Fe 3+ ‐mont) was found to be an effective and a reusable heterogeneous acid catalyst for the Michael addition of indole with methyl vinyl ketone at 333 K in H 2 O to afford 4‐(1 H ‐indol‐3‐yl)butan‐2‐one in high yields. Investigations on activity of the Fe 3+ ‐mont catalyst for deprotection of acetal and Meerwein‐Ponndorf‐Verley (MPV) reduction of aldehyde suggest that protonic acid sites of the Fe 3+ ‐mont catalyst are responsible for the present Michael addition of indole.