Premium
L‐ Proline Nitrate: An Amino Acid Ionic Liquid for Green and Efficient Conjugate Addition of Thiols to Sulfonamide Chalcones
Author(s) -
Bahekar Sandeep P.,
Agrawal Nikita R.,
Sarode Prashant B.,
Agrawal Abhijeet R.,
Chandak Hemant S.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701891
Subject(s) - thiophenol , sulfonamide , nucleophile , chemistry , electrophile , ionic liquid , umpolung , conjugate , acetonitrile , solvent , nitrate , organic chemistry , combinatorial chemistry , adduct , catalysis , mathematical analysis , mathematics
Abstract L ‐Proline nitrate catalysed simple, mild and efficient protocol for the synthesis of thia‐Michael adducts of sulfonamide chalcones has been described. L ‐Proline nitrate facilitates the electrophilic activation of sulfonamide enones with acetonitrile as optimum dielectric constant of the solvent increases nucleophilicity of thiophenol. The present protocol features benefits such as mild reaction conditions, operational simplicity and excellent yields.