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A DNA‐NDI Hybrid to Efficiently Detect Histone in Parts per Trillion (ppt) Level
Author(s) -
Pramanik Bapan,
Ahmed Sahnawaz,
Roy Rupam,
Das Basab K.,
Singha Nilotpal,
Das Debapratim
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701888
Subject(s) - histone , dna , chemistry , microbiology and biotechnology , biochemistry , biology
To develop a new sensor for histone, a series of Naphthalenediimide (NDI) derivatieves were subjected to DNA binding studies and the NDI derivative with strongest affinity for DNA was selected. This NDI‐DNA hybrid is used for highly selective and sensitive detection of a DNA binding protein, histone which dislodges the intercalated NDI groups and thus “turn‐on” the emission.