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Engineering Cell Surface Glycans with Carbohydrate Enantiomers to Alter Bacterial Binding and Adhesion
Author(s) -
Gade Madhuri,
Chaudhary Preeti Madhukar,
Thulasiram Hirekodathakallu V.,
Kikkeri Raghavendra
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701875
Subject(s) - glycan , chemistry , cell adhesion , chirality (physics) , bioorthogonal chemistry , biochemistry , carbohydrate , enantiomer , hela , adhesion , cell , mannose , cell adhesion molecule , microbiology and biotechnology , biophysics , glycoprotein , stereochemistry , combinatorial chemistry , biology , organic chemistry , click chemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Chirality of carbohydrate has critical functions in many biological processes. Changes in the configuration of even one sugar molecules may cause abnormal behavior or even inhibit specific processes. Herein, we have shown bioorthogonal conjugation of mannose enantiomers on HeLa cell surfaces induced a different rate of bacterial binding and cell adhesion.