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Synthesis of Lapachone Derivates via Ionic Liquid‐Mediated Tandem Knoevenagel/Diels‐Alder Reaction
Author(s) -
Prado Karinne E.,
Name Luccas L.,
Oliveira Rayssa P.,
Guadagnin Rafael C.,
Pimenta Daniel C.,
Pena Jesus M.,
Cella Rodrigo
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701861
Subject(s) - knoevenagel condensation , ionic liquid , diels–alder reaction , tandem , catalysis , lawsone , chemistry , organic chemistry , substrate (aquarium) , combinatorial chemistry , materials science , oceanography , composite material , geology
The use of ionic liquid (IL) in Tandem Knoevenagel/Diels‐Alder Reaction is an optimization method for one‐pot procedures, providing great results under mild conditions. In this paper, four new Lapachone derivatives were obtained using lawsone as substrate. The effects of the catalytic use of ionic liquids and catalysts in organometallic systems were evaluated. Several lapachone derivatives were obtained good to excellent yields.