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Enantioseparation of Flavanoids, Isoxazolines, Dansyl Amino Acids and β‐Blockers on Native and Phenylcarbamoylated α, β and γ‐Cyclodextrin Chiral Stationary Phases
Author(s) -
Jin Xuan,
Kang Qing,
Wang Yong
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701847
Subject(s) - chemistry , cyclodextrin , high performance liquid chromatography , thermogravimetric analysis , chromatography , elemental analysis , enantiomer , derivatization , organic chemistry
In this study, a series of native and p ‐methylphenylcarbamoylated cyclodextrin chiral stationary phases (CD‐CSPs) were developed based on α, β and γ‐cyclodextrin via ether linkage. The as‐prepared CSPs were characterized by FTIR, solid‐state C 13 NMR, thermogravimetric analysis and elemental analysis. Their enantioseparation properties were comprehensively investigated by using high performance liquid chromatography (HPLC) with various racemates including flavanoids, isoxazolines, dansyl amino acids and β‐blockers. The effects of CD cavity size and CD functionalities on the enantioseparation results were evaluated in detail. The correlation between analyte structures and their chiral resolution were also investigated. A reference chart has been proposed for quick choice of CD‐CSPs for enantioseparation of specific racemates.