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NIR Fluorescent AzaBODIPY‐Based Probe for the Specific Detection of L–Lysine
Author(s) -
Jiang XinDong,
Yue Shuai,
Jia Lei,
Li Shuang,
Li Congling,
Li Qian,
Xiao Linjiu
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701809
Subject(s) - lysine , fluorescence , nucleophile , chemistry , combinatorial chemistry , biochemistry , amino acid , physics , optics , catalysis
With 1‐(5‐chloro‐thiophen‐2‐yl)‐ethanone as the starting material, 3,5‐dichloro‐azaBODIPY 2 was successfully prepared. AzaBODIPY can be modified by nucleophilic monosubstitution with N‐nucleophile at room temperature. Since the previous work on specifically detecting L‐lysine (Lys) is scarce, dichloro‐azaBODIPY 2 is valuable as a probe for detecting Lys. Probe 2 was found to be selective and sensitive to Lys. Moreover, probe 2 can be used to detect Lys in PC3 cells, indicating its potential application for studying the effect of Lys in biological systems.