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Regioselective Synthesis of 2‐(Trifluoromethyl)‐3‐ethoxycarbonyl‐4‐(2‐oxo‐2‐arylethyl)‐4 H ‐chromene Derivatives by [3, 3] Sigmatropic Rearrangement
Author(s) -
Kuchukulla Ratnakar Reddy,
Desagoni Madhu,
Narra Srikanth Reddy,
Goutham Santhosh Kumar,
Banda Narsaiah
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701723
Subject(s) - trifluoromethyl , sigmatropic reaction , regioselectivity , acetylene , chemistry , medicinal chemistry , aryl , catalysis , organic chemistry , alkyl
Abstract A new and an efficient method has been developed to synthesize ethyl 4‐(2‐oxo‐2‐arylethyl)‐2‐(trifluoromethyl)‐4 H ‐chromene‐3‐carboxylate derivatives 3 from 2 H ‐chromene 1 and aryl acetylene 2 through [3, 3] sigmatropic rearrangement in presence of catalytic amount of BF 3 . OEt 2 (10 mol %).