Regioselective Synthesis of 2‐(Trifluoromethyl)‐3‐ethoxycarbonyl‐4‐(2‐oxo‐2‐arylethyl)‐4 H ‐chromene Derivatives by [3, 3] Sigmatropic Rearrangement | Zendy

Kuchukulla Ratnakar Reddy | Zendy; Desagoni Madhu | Zendy; Narra Srikanth Reddy | Zendy; Goutham Santhosh Kumar | Zendy; Banda Narsaiah | Zendy

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Regioselective Synthesis of 2‐(Trifluoromethyl)‐3‐ethoxycarbonyl‐4‐(2‐oxo‐2‐arylethyl)‐4 H ‐chromene Derivatives by [3, 3] Sigmatropic Rearrangement

Author(s) -

Kuchukulla Ratnakar Reddy,

Desagoni Madhu,

Narra Srikanth Reddy,

Goutham Santhosh Kumar,

Banda Narsaiah

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201701723

Subject(s) - trifluoromethyl , sigmatropic reaction , regioselectivity , acetylene , chemistry , medicinal chemistry , aryl , catalysis , organic chemistry , alkyl

A new and an efficient method has been developed to synthesize ethyl 4‐(2‐oxo‐2‐arylethyl)‐2‐(trifluoromethyl)‐4 H ‐chromene‐3‐carboxylate derivatives 3 from 2 H ‐chromene 1 and aryl acetylene 2 through [3, 3] sigmatropic rearrangement in presence of catalytic amount of BF 3 . OEt 2 (10 mol %).

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