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Oxidized Carbon Black as Catalyst for the Enamine Formation in Solvent‐Free Conditions: A Green Strategy to Build the Benzodiazepine Scaffold
Author(s) -
Villano Rosaria,
Acocella Maria Rosaria,
Guerra Gaetano
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701711
Subject(s) - enamine , catalysis , chemistry , solvent , carbon black , combinatorial chemistry , scaffold , carbon fibers , environmentally friendly , organic chemistry , chemical engineering , materials science , computer science , engineering , composite material , ecology , natural rubber , composite number , biology , database
Oxidized carbon black efficiently catalyzed addition of amines to 1,3‐dicarbonyl compounds under solvent‐free conditions at room temperature. This methodology is eco‐friendly and cheap, with a very easy work up and the possibility to recover and recycle the catalyst. Finally, the elaborated methodology can be conveniently exploited for the synthesis of 1,5‐benzodiazepine.