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Greener and Additive‐Free Reactions in Deep Eutectic Solvent: One‐Pot, Three‐Component Synthesis of Highly Substituted Pyridines
Author(s) -
Azizi Najmedin,
Haghayegh Mehran Shahiri
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701682
Subject(s) - malononitrile , deep eutectic solvent , catalysis , eutectic system , chemistry , solvent , reuse , environmentally friendly , reaction conditions , organic chemistry , production cost , green chemistry , combinatorial chemistry , reaction mechanism , waste management , mechanical engineering , ecology , alloy , engineering , biology
One‐step synthesis of highly substituted pyridines via a multicomponent reaction of structurally diverse aldehydes with various thiols and malononitrile using deep eutectic solvent (DES) as green reaction media and catalyst is presented. This catalyst‐free, cost‐effective, and environmentally benign protocol utilizes recyclable reaction media, it is amenable to large scale production without significant loss in efficiency giving the desired compounds in short reaction times with moderate to good yields (60–82%). The inexpensive DES showed excellent recyclability using a simple recovery and reuse system without loss of parent catalytic activity even after three cycles.