Metal‐Free, Oxidant‐Free, Site‐Selective C−H Halogenations to Aminoquinolines at Room Temperature using  N ‐Halosaccharins | Zendy

Dutta Himangsu Sekhar | Zendy; Khan Bhuttu | Zendy; Khan Afsar Ali | Zendy; Ahmad Ashfaq | Zendy; Kant Ruchir | Zendy; Koley Dipankar | Zendy

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Metal‐Free, Oxidant‐Free, Site‐Selective C−H Halogenations to Aminoquinolines at Room Temperature using N ‐Halosaccharins

Author(s) -

Dutta Himangsu Sekhar,

Khan Bhuttu,

Khan Afsar Ali,

Ahmad Ashfaq,

Kant Ruchir,

Koley Dipankar

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201701649

Subject(s) - halogenation , regioselectivity , chemistry , organic chemistry , combinatorial chemistry , catalysis

We report a metal‐free, oxidant‐free, highly regioselective halogenations protocol (chlorination, bromination and iodination) to amidoquinolines using N ‐halosaccharin derivatives. Various amidoquinolines are tolerated by the method and delivered C5‐haloamidoquinoline derivates in excellent yields. A homo and hetero bis‐halogenation protocol has also been established. Late stage drug molecule diversification has also been demonstrated using the developed protocol.

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