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Aqueous Dispersions of Unmodified Y@C 82 ( C 2v ) Endohedral Metallofullerene
Author(s) -
Mikheev Ivan V.,
Kareev Ivan E.,
Bubnov Vyacheslav P.,
Volkov Dmitriy S.,
Korobov Mikhail V.,
Proskurnin Mikhail A.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701557
Subject(s) - aqueous solution , metallofullerene , toluene , chemistry , yield (engineering) , zeta potential , solvent , aqueous two phase system , analytical chemistry (journal) , fullerene , materials science , chromatography , organic chemistry , nanoparticle , nanotechnology , metallurgy
Aqueous dispersions of an unmodified (pristine) ( AFD ) nY@C 82 (symmetry C 2v ) endofullerene were produced with a nearly 100% yield relative to the initial toluene solution of the endofullerene. To the best of our knowledge, this is the first report of this kind of endofullerene aqueous dispersions. The solvent‐exchange ultrasound‐assisted procedure requires no modification of the endofullerene surface or addition of any stabilizing agents into the aqueous phase. The procedure is applicable to any endohedral metallofullerene aqueous dispersions suitable for biomedical applications. The resulting dispersions are stable for at least 6 months. For the produced aqueous dispersions of Y@C 82 , the zeta potential of ca . –42 mV shows good stability; the average diameter of clusters was as small as ca . 120 nm. Techniques for purification and purity control of nY@C 82 and of the intermediate toluene solution of Y@C 82 were developed. The residual quantity of organic compounds was less than 1 ppb after the purification. Based on ICP–AES, headspace GC–MS, and MALDI–TOF, a procedure to assess endofullerene concentrations in the aqueous phase was proposed.