Iron Catalyzed Oxidative C(sp 3 )–N Cross Coupling of Amides with C(sp 3 )–H via a Radical Process | Zendy

Li Zelin | Zendy; Cai Chun | Zendy

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Iron Catalyzed Oxidative C(sp 3 )–N Cross Coupling of Amides with C(sp 3 )–H via a Radical Process

Author(s) -

Li Zelin,

Cai Chun

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201701537

Subject(s) - catalysis , chemistry , catalytic cycle , oxidative phosphorylation , alkylation , ligand (biochemistry) , oxidative coupling of methane , medicinal chemistry , oxidative addition , stereochemistry , organic chemistry , receptor , biochemistry

An efficient iron‐catalyzed oxidative N–H alkylation of amides with C(sp 3 )–H in cycloalkanes, methylarenes and tert‐Butyl peroxybenzoate was developed. This protocol proceeded smoothly without any ligand; and tolerated a broad range of substrates, not only various amides but also the inactive C(sp 3 )−H bond containing compounds. Mechanistic details involving a Fe(II)/Fe(III) catalytic cycle and a single electron transfer (SET)‐type process were also described.

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