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Evaluation of Antioxidant, Anti‐Inflammatory, Antibacterial Activity and In Silico Molecular Docking Study of Pyrazole Curcumin Bisacetamide Analogs
Author(s) -
Banuppriya Govindharasu,
Sribalan Rajendran,
Padmini Vediappen
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701533
Subject(s) - curcumin , chemistry , antioxidant , docking (animal) , staphylococcus aureus , ciprofloxacin , antibacterial activity , pyrazole , in vitro , anti inflammatory , stereochemistry , combinatorial chemistry , pharmacology , biochemistry , antibiotics , bacteria , biology , medicine , nursing , genetics
A series of pyrazole curcumin bisacetamides ( 4 a‐l ) were synthesized with excellent yield and in vitro antioxidant, anti‐inflammatory and antibacterial activities were studied. These compounds have shown marvelous antioxidant and anti‐inflammatory activities towards curcumin and standard drug. The compounds 4 d , 4 j , 4 l , have shown better antibacterial activity than ciprofloxacin and parent curcumin in both gram‐positive and gram‐negative bacterias. The compounds 4 j , 4 k , and 4 l have exhibited very good activity on methicillin‐resistant staphylococcus aureus when compared to standard oxacillin and parent curcumin. Further, the molecular docking studies revealed that the compounds 4 d and 4 l have shown better binding interaction with penicillin binding protein via five hydrogen bond interactions.