Development of a L‐Tryptophan‐Based Ligand for Regioselective Copper Catalyzed N 2 ‐Arylation of 1,2,3‐Triazoles

2‐aryl‐1,2,3‐triazoles are important compounds that find applications in Medicinal chemistry, diagnostics, catalysis and others. However, only few methodologies for their preparation is found in the literature. The development of a post cycloaddition N 2 selective arylation towards these compounds would benefit from a more convergent strategy. In the present communication, the development of a new tryptophan‐based ligand allowed the selective arylation of the N 2 ‐position of 1,2,3‐triazoles using recyclable CuFe 2 O 4 nanoparticles. This method was efficient in furnishing N 2 ‐arylated and heteroarylated 1,2,3‐triazoles in good yields and excellent N 2 ‐selectivity. The methodology developed found application in the synthesis of the 2‐aryl‐1,2,3‐triazoyl fragment of the drug suvorexant (Belsomra®).