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An Efficient, Facile Synthesis of Etoricoxib Substantially Free from Impurities: Isolation, Characterization and Synthesis of Novel Impurity
Author(s) -
Awasthi Arun Kumar,
Kumar Brijesh,
Aga Mushtaq A.,
Basha Shaik Thaslim,
Reddy Cirandur Suresh,
Kumar Pramod
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701410
Subject(s) - impurity , yield (engineering) , derivative (finance) , etoricoxib , combinatorial chemistry , salt (chemistry) , chemistry , materials science , organic chemistry , economics , financial economics , metallurgy
A copper mediated efficient, facile synthesis of Etoricoxib from commercial available keto sulfone and vinamidinium salt was developed. This protocol with mild reaction conditions offered the product with >80% overall yield and remarkable quality. During process development an unknown impurity was observed, isolated, characterized (by NMR, mass and IR spectroscopy) and was identified as Pyrrole derivative.