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A New Class of Boronic Acid‐Derived Amphiphile‐Based Gel Emulsions Capable of Entrapping and Releasing Vitamin B 12 and Doxorubicin
Author(s) -
Roy Sumita,
Maiti Monali,
Roy Aparna
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701397
Subject(s) - amphiphile , boronic acid , chemistry , micelle , salt (chemistry) , amide , emulsion , solvent , amphiphilic molecule , organic chemistry , polymer chemistry , copolymer , polymer , aqueous solution
In this work, two boronic acid based amphiphiles, Sodium salt of 2‐amidodecylpyridine‐5‐boronic acid (SADPB) and Sodium salt of 2‐amidododecylpyridine‐5‐boronic acid (SADDPB) have been synthesized and their gel‐emulsion property in organic solvents were investigated. The good gelation ability of the amphiphiles was confirmed by low minimum gelation concentration ( MGC ) and high gelation number ( N gel ) values. Theoretical study established that introduction of amide linkage in the amphiphilic structure dismantles aggregate formation. The gel‐emulsions are stable towards mechanical and thermal responses. The gelation process is also dependent on the nature of solvent and type of amphiphiles. The morphology of gel‐emulsions is highly dependent on the concentration of the amphiphile. The prepared gel‐emulsions are able to encapsulate and release biomolecule vitamin B 12 and anticancer drug doxorubicin at room temperature. Both vitamin B 12 and doxorubicin exhibited retention of their structures and activity which has been recognized this new type of boronic acid based amphiphiles as efficient drug delivery vehicles.