Premium
A Regioselective Synthesis of 2,5‐Diaryl Oxazoles via TsOH/I 2 ‐Mediated Cascade Cyclization
Author(s) -
Zhang Fangdong,
Wang Jing,
Zhang Xueguo,
Meng Xu,
Chen Baohua
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701390
Subject(s) - regioselectivity , phenylacetylene , oxazole , tandem , benzylamine , dehydrogenation , chemistry , combinatorial chemistry , cascade , cascade reaction , sulfonic acid , oxidative phosphorylation , organic chemistry , catalysis , materials science , chromatography , biochemistry , composite material
A concise and practical approach for synthesis of 2,5‐disubstituted oxazole has been developed via a TsOH( p ‐Methylbenzene sulfonic acid)/I 2 ‐mediated tandem dehydrogenation oxidative cyclization of phenylacetylene and benzylamine. Desired products in high yields have been obtained.