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Metal‐Free Remote C‐H Bond Acetoxylation of 8‐Aminoquinolines on the C5‐Position
Author(s) -
Thrimurtulu Neetipalli,
Dey Arnab,
Pal Kuntal,
Nair Akshay,
Kumar Shreemoyee,
Volla Chandra M. R.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701388
Subject(s) - regioselectivity , substrate (aquarium) , scope (computer science) , combinatorial chemistry , functional group , chemistry , position (finance) , metal , organic chemistry , computer science , catalysis , biology , finance , ecology , polymer , economics , programming language
Herein, we describe a simple and practical approach for the selective acetoxylation at the C5‐position of 8‐aminoquinoline amides under metal free conditions. Our strategy shows high conversion efficiency, broad substrate scope, and functional group tolerance giving access to various C5‐acetoxylated carboxamides, sulfonamides or phosphinamides in good yields. In addition, the reaction conditions are suitable to scale up and also exhibited high regioselectivity.