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Expedient Ytterbium Triflate Catalyzed One‐Pot Mulicomponent Synthesis of Spiro[indoline‐3, 4′‐pyrano[2, 3‐c]pyrazole]
Author(s) -
Muthuraja Perumal,
Prakash Sengodu,
Siva Govindaraj,
Muthusubramanian Shanmugam,
Manisankar Paramasivam
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701261
Subject(s) - ytterbium , trifluoromethanesulfonate , pyrazole , indoline , ethyl acetoacetate , chemistry , catalysis , atom economy , medicinal chemistry , one pot synthesis , solvent , organic chemistry , materials science , optoelectronics , doping
We have synthesized a set of multi‐substituted spiro[indoline‐3, 4’‐pyrano[2, 3‐c]pyrazole] from 5‐chloroisatin, substituted phenyl hydrazines, 2‐chloroacetonitrile/2‐bromoacetonitrile/2‐hydroxy‐1,4‐naphthaquionone and ethyl acetoacetate in the presence of ytterbium triflate as catalyst in one‐pot four component method at room temperature. The synthesized compounds are confirmed by FT‐IR, 1D and 2D NMR spectroscopic techniques. Green synthetic methodology is adopted for the using green solvent ethanol, low temperature and easy work up which resulted in higher atom economy.