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Ring Functionalization and Molecular Hybridization of Quinolinyl Pyrazole: Design, Synthesis and Antimycobacterial Activity
Author(s) -
Rachakonda Venkatesham,
Kotapalli Sudha Sravanti,
Ummanni Ramesh,
Alla Manjula
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701241
Subject(s) - pyrazole , moiety , antimycobacterial , chemistry , surface modification , combinatorial chemistry , stereochemistry , triazole , quinoline , mycobacterium smegmatis , ring (chemistry) , click chemistry , organic chemistry , mycobacterium tuberculosis , medicine , tuberculosis , pathology
Synthesis of quinolinyl pyrazole analogues by ring functionalization as well as molecular hybridization strategy is adopted. Diverse functional groups were assembled around the privileged scaffold viz., 2‐methyl‐3‐(1 H ‐pyrazol‐5‐yl)quinoline. A series of quinolinyl pyrazole analogues with 1,4‐disubstituted 1,2,3‐triazole moiety, were synthesized employing Click reaction conditions. All 29 synthesized were evaluated for antitubercular activity against Mycobacterium smegmatis strain; wherein eight compounds were active and two promising. Compounds also exhibited the low cytotoxicity against A549 cell line.