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Synthesis of Novel 5‐Substituted 6‐Phenylpyrrolo[2, 3‐ d ]pyrimidine Derivatives via One‐pot Three‐Component Reactions Under Catalyst‐Free Condition
Author(s) -
Saroha Mohit,
Khanna Garima,
Khurana Jitender M.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701234
Subject(s) - phenylglyoxal , pyrimidine , methylene , chemistry , catalysis , ethanol , condensation , component (thermodynamics) , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , amino acid , biochemistry , physics , arginine , thermodynamics
An efficient synthesis of some novel 5‐subsituted 6‐phenyl pyrrolo[2, 3‐ d ]pyrimidine derivatives has been reported. The 5‐substitution has been reported with indoles, 1 H ‐pyrazol‐5(4 H )‐one, and various heterocyclic/carbocyclic active methylene compounds. The synthesis has been achieved by one‐pot three‐component condensation of phenylglyoxal, 6‐amino‐1,3‐dimethyluracil and substituted indoles/1 H ‐pyrazol‐5(4 H )‐one/ active methylene compounds in ethanol at reflux temperature under catalyst‐free condition.