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Gold Nanoparticles and Reduced Graphene Oxide‐Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment
Author(s) -
Jafarizad Abbas,
Aghanejad Ayuob,
Sevim Melike,
Metin Önder,
Barar Jaleh,
Omidi Yadollah,
Ekinci Duygu
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701178
Subject(s) - colloidal gold , drug delivery , nanotechnology , graphene , materials science , nanomaterials , nanoparticle , covalent bond , conjugated system , nanomedicine , targeted drug delivery , nanocomposite , chemistry , organic chemistry , polymer , composite material
AuNPs and AuNPs/RGO composites were engineered as drug delivery nanoplatforms to efficiently deliver the anti‐cancer drug to MCF‐7 breast cancer cells. The anti‐cancer drug, mitoxantrone (MTX), was tethered to the gold nanoparticles via a 3‐mercaptopropionic acid (MPA) spacer and an acid‐cleavable amid bond (SMTX‐AuNPs). Then, the surface of the RGO nanosheets were decorated with SMTX‐AuNPs (SMTX‐AuNPs/RGO). For comparison purposes, MPA functionalized nanoparticles (MPA‐AuNPs) and their nanocomposites (MPA‐AuNPs/RGO) were also prepared using the same procedure. The formation of the nanomaterials was verified by spectroscopic and morphological techniques. The drug delivery activity of materials on MCF‐7 cells was investigated in vitro using different methods. Our results demonstrate that SMTX‐AuNPs have better activity on cancer cells than free MTX and SMTX‐AuNPs/RGO. Further, contradicting previous studies, our findings suggest that the use of graphene‐based materials for the covalent drug delivery systems need to be revisited.