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A Quick, Simple and Clean Synthesis of Spiro(indoline‐3,4′‐pyrazolo[4′, 3′:5,6]pyrido[2, 3‐ d ]pyrimidines) in Water through a Novel One‐Pot Multicomponent Reaction
Author(s) -
Kalita Subarna Jyoti,
Das Bidyut,
Deka Dibakar Chandra
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701131
Subject(s) - chemistry , yield (engineering) , indoline , toluene , solvent , sulfonic acid , isatin , catalysis , reaction conditions , combinatorial chemistry , simple (philosophy) , organic chemistry , materials science , philosophy , epistemology , metallurgy
Abstract A novel and general protocol for quick, simple and efficient synthesis of spiro[indoline‐3, 4′‐pyrazolo[4′, 3′:5,6]pyrido[2, 3‐ d ]pyrimidines] via one‐pot three component reactions of isatins, 5‐aminopyrazoles and 6‐aminouracils or 2,6‐diaminopyrimidin‐4‐one in water catalyzed by para ‐toluene sulfonic acid monohydrate ( p ‐TSA.H 2 O) under mild reaction conditions has been described. Use of water as the solvent system, application of mild and cost‐effective solid p ‐TSA.H 2 O as organocatalyst, high yield in short reaction time, simple purification process with no chromatographic technique and operational simplicity make the protocol highly attractive.