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ESIPT‐Based Nanomolar Zn 2+ Sensor for Human Breast Cancer Cell (MCF7) Imaging
Author(s) -
Ghosh Milan,
Ghosh Abhijit,
Ta Sabyasachi,
Matalobos Jesús S.,
Das Debasis
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701102
Subject(s) - chemistry , fluorescence , chelation , human breast , selectivity , isomerization , aqueous solution , photochemistry , cancer cell , cancer , inorganic chemistry , biochemistry , physics , quantum mechanics , catalysis , medicine
A single crystal X‐ray structurally characterized probe (L), derived from 2‐amino‐1‐phenylpropan‐1‐ol and 2‐hydroxy‐1‐napthaldehyde selectively recognizes nano‐molar Zn 2+ both by fluorescence and colorimetric method. Inhibition of excited‐state intra‐molecular proton transfer (ESIPT) and ‐CH=N isomerization along with chelation‐enhanced fluorescence (CHEF) collectively contribute to Zn 2+ recognition. L exhibits excellent sensitivity (2×10 −9 M) and selectivity for Zn 2+ in aqueous DMSO (1:1, v/v) media and useful for intra‐cellular Zn 2+ imaging in human breast cancer cells (MCF7).