ESIPT‐Based Nanomolar Zn 2+  Sensor for Human Breast Cancer Cell (MCF7) Imaging | Zendy

Ghosh Milan | Zendy; Ghosh Abhijit | Zendy; Ta Sabyasachi | Zendy; Matalobos Jesús S. | Zendy; Das Debasis | Zendy

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ESIPT‐Based Nanomolar Zn 2+ Sensor for Human Breast Cancer Cell (MCF7) Imaging

Author(s) -

Ghosh Milan,

Ghosh Abhijit,

Ta Sabyasachi,

Matalobos Jesús S.,

Das Debasis

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201701102

Subject(s) - chemistry , fluorescence , chelation , human breast , selectivity , isomerization , aqueous solution , photochemistry , cancer cell , cancer , inorganic chemistry , biochemistry , physics , quantum mechanics , catalysis , medicine

A single crystal X‐ray structurally characterized probe (L), derived from 2‐amino‐1‐phenylpropan‐1‐ol and 2‐hydroxy‐1‐napthaldehyde selectively recognizes nano‐molar Zn 2+ both by fluorescence and colorimetric method. Inhibition of excited‐state intra‐molecular proton transfer (ESIPT) and ‐CH=N isomerization along with chelation‐enhanced fluorescence (CHEF) collectively contribute to Zn 2+ recognition. L exhibits excellent sensitivity (2×10 −9 M) and selectivity for Zn 2+ in aqueous DMSO (1:1, v/v) media and useful for intra‐cellular Zn 2+ imaging in human breast cancer cells (MCF7).

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