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An Efficient Ecofriendly Enantioselective Organocatalytic Ring‐Closing Reaction of 2‐Hydroxychalcone via Intramolecular Oxa‐Michael Reaction
Author(s) -
Singh Ashawani Kumar,
Mangawa Shrawan Kumar,
Kumar Arvind,
Dixit A. K.,
Awasthi Satish Kumar
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701047
Subject(s) - flavanone , intramolecular force , enantioselective synthesis , michael reaction , yield (engineering) , organocatalysis , chemistry , substrate (aquarium) , combinatorial chemistry , catalysis , ring (chemistry) , organic chemistry , stereochemistry , materials science , biology , ecology , flavonoid , metallurgy , antioxidant
An organocatalyzed highly asymmetric cascade oxa‐Michael addition reaction for the synthesis of flavanone from 2‐hydroxychalcone has been developed. This method works well with low catalyst loading and has broad range substrate scope, furnishing the desired product in excellent yield and displays an intrinsic enantioselectivity of upto 99.9 % ee . This method provides a straightforward entry into highly functionalized chiral flavanone derivatives.