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Polyethyleneimine‐Polyoxometalate‐Based Supramolecular Self‐assembled pH‐Responsive Hydrogels: Formulation and in vitro Evaluation
Author(s) -
Haider Ali,
Kortz Ulrich,
Joshi Sachin A.,
Iqbal Jamshed
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201701003
Subject(s) - self healing hydrogels , polymer chemistry , cationic polymerization , chemistry , polyacrylic acid , supramolecular chemistry , hela , acrylic acid , swelling , kinetics , nuclear chemistry , polymerization , chitosan , cytotoxicity , chemical engineering , in vitro , organic chemistry , polymer , biochemistry , monomer , physics , quantum mechanics , crystal structure , engineering
In the present study electrostatically‐driven pH responsive supramolecular, self‐assembled hydrogels of the trilacunary Wells‐Dawson‐type 15‐tungsto‐2‐phosphate polyanion [P 2 W 15 O 56 ] 12− ( P 2 W 15 ) and polyethyleneimine were prepared. Crosslinking was achieved through electrostatic interactions between cationic polyethyleneimine and P 2 W 15 . The pH responsiveness was induced by acrylic acid. Benzoyl peroxide was used as an initiator, for initiating the polymerization reaction, anchoring polyacrylic acid on the polyethyleneimine skeleton. The prepared sea‐green color hydrogels were characterized by FT‐IR, SEM, XRD and thermal analysis (TGA‐DSC). The swelling index, P 2 W 15 release studies and pH responsive properties of the developed supramolecular hydrogels were evaluated at pH 1.2 and 7.4, showing maximum swellability and release characteristics at pH 7.4. For determining the P 2 W 15 release mechanism different mathematical models such as zero order, first order, Higuchi model and Krosmeyer‐Peppas models were applied and the results showed that embedded P 2 W 15 release follows zero‐order kinetics. The cytotoxicity results showed that naked and embedded P 2 W 15 exhibited dose‐dependent cytotoxicity against cancer cell lines (MCF‐7; Hela) with minimal effects on normal cells (Vero). The hydrogels developed through electrostatic interactions exhibited desirable qualities of a drug delivery system that can be used for the delivery of the embedded polyanion.