Premium
Cobalt and Copper Co–Catalyzed Three‐Component Reactions for the Synthesis of 1,3,4‐Trisubstituted Pyrazoles
Author(s) -
Wei Daidong,
Ma Haojie,
Zhou Xiaoqiang,
Shi Chong,
Luo Xinliang,
Huang Guosheng
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700987
Subject(s) - cobalt , nitromethane , catalysis , copper , chemistry , combinatorial chemistry , substrate (aquarium) , component (thermodynamics) , organic chemistry , oceanography , geology , physics , thermodynamics
A novel cobalt and copper co‐catalyzed for exclusive synthesis of 1,3,4‐trisubstituted pyrazoles via a one‐pot reaction of hydrazones with nitromethane and aldehydes has been reported. Proper conditions without additional oxidants, broad substrate scope and easily obtained starting materials make this protocol promising and practical.