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Cover Picture: A Simple and Sensitive 19 F NMR Approach for Studying the Interaction of RNA G‐Quadruplex with Ligand Molecule and Protein (ChemistrySelect 15/2017)
Author(s) -
Bao HongLiang,
Ishizuka Takumi,
Iwanami Ayaka,
Oyoshi Takanori,
Xu Yan
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700980
Subject(s) - fluorine 19 nmr , ligand (biochemistry) , rna , chemistry , nuclear magnetic resonance spectroscopy , molecule , small molecule , nuclear magnetic resonance spectroscopy of nucleic acids , chemical shift , nmr spectra database , nucleic acid structure , computational chemistry , stereochemistry , crystallography , spectral line , transverse relaxation optimized spectroscopy , biochemistry , organic chemistry , physics , receptor , gene , astronomy
The cover picture shows that 19 F NMR has been successfully used to investigate the interaction of RNA G‐quadruplex with ligand molecule and protein. RNA G‐quadruplex structures have recently received considerable attention in research. They have emerged as potential targets for drug design because of their biological importance. Due to the high sensitivity of the 19 F chemical shift to the environment, 100 % natural abundance of 19 F, and relative simplicity of 19 F NMR spectra, 19 F NMR can provide useful information to elucidate the binding events for RNA G‐quadruplexes with ligand and protein molecules, which is not easy to do using other methods, such as CD and 1 H NMR spectroscopy. More information can be found in the Full Paper by Bao et al. (DOI: 10.1002/slct.201700711).