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Catalyst‐Free Synthesis for Pyrazole‐Fused Isocoumarins in Recyclable and Biodegradable Reaction Medium
Author(s) -
Yadav Vijay B.,
Rai Pragati,
Sagir Hozeyfa,
Kumar Akhilesh,
Siddiqui Ibadur R.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700976
Subject(s) - isocoumarins , pyrazole , simplicity , combinatorial chemistry , chemistry , ninhydrin , catalysis , biochemical engineering , computer science , organic chemistry , engineering , biochemistry , philosophy , epistemology , amino acid
An efficient and facile protocol for the synthesis of pyrazole‐fused isocoumarins via reactions of readily available ninhydrin and arylhydrazone is disclosed. This approach illustrate operational simplicity, offering a modified and expedient methodology for the direct construction of synthetically useful pyrazole‐fused isocoumarins compounds in good to excellent yields. This documented strategy, provide a cost effective and environmentally benign alternative to the other existing method.