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Competitive‐Binding Activated Supramolecular Nanovalves Based on β‐Cyclodextrin Complexes
Author(s) -
Liu Zongjun,
Shi Junhui,
Han Renlu,
Wang Hao,
Wang You,
Gan Yang
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700956
Subject(s) - supramolecular chemistry , cyclodextrin , chemistry , competitive binding , molecule , mesoporous silica , pyrene , isothiocyanate , mesoporous material , nanotechnology , combinatorial chemistry , organic chemistry , materials science , catalysis , biochemistry , receptor
Competitive binding activated nanovalves (CBAN) with on‐demand activation capability are fabricated through switching from host‐guest complexation to decomplexation upon the introduction of competitive guest (C‐guest) molecules. Guest molecules of pyrene or naphthalene are used to associate with β ‐cyclodextrin ( β ‐CD) host to form supramolecular complexes. These supramolecular conjugations were assembled on the surface of mesoporous silica nanoparticles (MSNs), which played a role of “nanovalve” for blocking the nanopores. For the activation of nanovalves, C‐guest of 1‐adamantanamine hydrochloride (Ad), was added to dissociate formerly assembled complex by competitive binding with host β ‐CD. In controlled release study, the fabricated CBAN was stable at “Off” state for preventing cargo release, and able to release the cargo efficiently at “On” state. Moreover, the competitive binding process was also investigated by using fluorescein isothiocyanate modified β ‐CD. It was found that the shift of host‐guest complexation equilibrium by C‐guest activates the CBAN. These results would shed lights on the development of novel supramolecular nanovalves.