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Catalyst‐Free and One‐Pot Procedure for Fast Formation of α‐Ketoamides Using α‐Oxocarboxylic Acids and Amines at Room Temperature
Author(s) -
Liu Fuyan,
Liu Yaxu,
Chen Yiping,
Sun Zhongliang,
Wang Bo
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700923
Subject(s) - catalysis , stoichiometry , chemistry , primary (astronomy) , organic chemistry , combinatorial chemistry , polymer chemistry , physics , astronomy
A highly efficient, one‐pot, and catalyst‐free approach for fast synthesis of an array of α‐ketoamides starting from easily obtainable α‐oxocarboxylic acids and primary‐/secondary‐ amines has been developed via in situ activation of acids using stoichiometric 2,4,6‐trichloro‐1,3,5‐trizaine at room temperature, reactions could proceed smoothly to provide the corresponding α‐ketoamides in good to excellent yields of up to 99 %.