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Polybenzimidazole‐Triphenylphosphene‐Catalyzed One‐Pot Synthesis and Evaluation of Dihydropyridine Derivative as Antibiotics and Antifungals
Author(s) -
Perumal Muthuraja,
Sengodu Prakash,
Venkatesan Sethuraman,
Perumal Sathiaseelan,
Antony Susaimanickam,
Paramsivam Manisankar
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700918
Subject(s) - catalysis , chemistry , carbon 13 nmr , derivative (finance) , proton nmr , antibacterial activity , combinatorial chemistry , nuclear chemistry , organic chemistry , stereochemistry , medicinal chemistry , bacteria , biology , financial economics , economics , genetics
Dihydropyridines derivative have been synthesized by one‐pot multicomponent cyclocondensation reaction using PBI‐PPh 3 catalyst. This catalyst is characterized by the solid state of 13 C‐NMR, 15 N‐NMR, and 31 P‐NMR spectrum, FT‐IR, cyclic voltammetry, and XRD analysis. The selection of catalyst is quite interesting because of its affordability, toxic free nature and high stability. Functional groups of all dihydropyridines confirms by H 1 ‐NMR and FTIR spectra. Synthesized compounds show exceptional yields of 96–99 %. Synthesized compounds has evaluated for their invitro antibacterial activity against B. subtilis , and P. vulgaris (ATCC 49565) and C. albicans (ATCC 90028). Synthesized dihydropyridines showed promising antibacterial and antifungal activities, in particularly, ethyl‐4‐(4‐methylphenyl)‐2,7,7‐trimethyl‐5‐oxo‐1,4,5,6,7,8‐hexadihydropyridine‐3‐carboxylate are exhibiting a higher inhibition zone of 66.7 % against bacteria. Our method may help to drug chemists for design more interesting, useful, and sustainable reactions in the near future.