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Stereoselective Total Syntheses of ( R )‐Strongylodiols A, B, C and D
Author(s) -
Gangadhar Pamarthi,
Rajesh Pallavagary,
Pabbaraja Srihari
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700898
Subject(s) - stereoselectivity , total synthesis , propargyl alcohol , chemistry , tartrate , alkoxy group , stereochemistry , alcohol , propargyl , chloride , organic chemistry , catalysis , alkyl
A facile stereoselective approach for the total syntheses of ( R )‐strongylodiols A, B, C and D is described. A chiron approach has been followed wherein the stereochemistry at the chiral center is fixed and a methodology of base induced elimination of β‐alkoxy chloride to get the chiral propargyl alcohol is employed. A key intermediate synthesized from commercially available (‐)‐diethyl D‐ tartrate has been utilized for the total syntheses of all the four titled compounds.