Premium
A‐One Pot Four Component and Microwave‐Assisted Synthesis of Pyrrolo [1, 10]phenanthrolines
Author(s) -
Dhinakaran Isaivani,
Padmini Vediappen,
Ganesan Kumaresan,
Selvarasu Karthikeyan
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700819
Subject(s) - chemistry , ketoconazole , cancer cell lines , erythromycin , candida albicans , microwave , combinatorial chemistry , stereochemistry , cancer , antibiotics , antifungal , microbiology and biotechnology , cancer cell , biochemistry , biology , medicine , physics , quantum mechanics
Microwave‐assisted synthesis of pyrrolo[1, 10]‐phenanthrolines in a one pot four component approach afforded a wide range of products within 3 minutes. All the compounds were screened for their biological activities such as anti‐microbial and anti‐cancer activities. Compounds 5 b, 5 c, 5 i, 5 m and 5 n have shown more potent activity when compared to standard doxorubicin against AGS cancer cell line and compounds 5 d and 5 l show more potent microbial activity against MRSA, B. Subtilis and C. Albicans when compared to standard Erythromycin, Oxacillin and Ketoconazole