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Iridium‐Catalyzed Cyclization of o ‐Aminobenzamides with Unsaturated Aldehydes to Give 2‐Alkylquinazolinones through a Hydrogen Autotransfer Process
Author(s) -
Zhao Wei,
Ma Wangjing,
Xiao Tiancun,
Li Feng
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700780
Subject(s) - iridium , catalysis , chemistry , hydrogen , hydrogen atom , process (computing) , product (mathematics) , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematics , computer science , operating system , alkyl , geometry
The synthesis of 2‐alkylquinazolinones via iridium‐catalyzed cyclization of o ‐aminobenzamides with unsaturated aldehydes has been accomplished. In the presence of [Cp*IrCl 2 ] 2 , a series of desirable products were obtained in 77–91 % yields. This strategy is attractive due to high atom efficiency and the formation of water as the only side product.