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[3+2] Cycloaddition of 3‐Diazooxindole with Arynes for the Synthesis of Spiro[indazole‐3,3′‐indolin]‐2′‐ones
Author(s) -
Subba Reddy Basi V.,
Gopi Reddy Raveendra Reddy,
Reddy Thummaluru Veera,
Sridhar Balasubramanian
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700715
Subject(s) - aryne , indazole , cycloaddition , trimethylsilyl , chemistry , fluoride , intermolecular force , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , molecule , inorganic chemistry
An intermolecular cycloaddition between 3‐diazooxindoles and arynes generated in situ from 2‐(trimethylsilyl)phenyltrifluoromethanesulfonate in the presence of 2.5 mol% cesium fluoride has been achieved to produce a novel series of spiro[indazole‐3,3′‐indolin]‐2′‐one derivatives in good yields under mild experimental conditions. It is an elegant strategy for the quick construction of a highly rigid spirocyclic compounds in a single step.
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