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Synthesis of Carboxamide‐Functionalized Multiwall Carbon Nanotubes via Ugi Multicomponent Reaction: Water‐Dispersible Peptidomimetic Nanohybrid as Controlled Drug Delivery Vehicle
Author(s) -
Shaabani Ahmad,
Afshari Ronak
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700615
Subject(s) - peptidomimetic , zeta potential , ugi reaction , surface modification , biocompatibility , carbon nanotube , drug delivery , nanotechnology , chemistry , combinatorial chemistry , dispersity , carboxamide , materials science , organic chemistry , nanoparticle , isocyanide , peptide , biochemistry
This paper describes a direct synthesis of novel and valuable carboxamide functionalized multiwall carbon nanotubes (carboxamide‐ f ‐MWCNTs) for the development of new nanovectors through covalent functionalization via a one‐pot four‐component Ugi reaction. This efficient synthetic approach is facile and straightforward procedure for the synthesis of peptidomimetic coated MWCNTs from simple and readily starting materials including aniline, benzaldehyde, isocyanide and the carboxylated MWCNT as an acid component. The new synthesized nanobiohybrid was fully characterized. Also, the stability of nanobiohybrid was assessed using Zeta potential and particle size analyses. The synthesized nanobiohybrid presents unprecedented high and long term dispersity and stability in water. The performance of the nanobiohybrid for the controlled release of folic acid, as a model drug, was investigated and the results depicted pH dependent slow drug release behavior of nanobiohybrid. In addition, biocompatibility and cytotoxicity of carboxamide‐ f ‐MWCNTs were examined and no obvious adverse effects on the viability of NIH‐3T3 cells were observed. The results manifested its valuable applicability in controlled release drug delivery systems.