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Highly Regioselective Debus‐Radziszewski Reaction of C‐3 Indole‐Substituted 1,2‐Diketones: Facile Synthesis of 3‐(1,2,4‐Triaryl‐1 H ‐imidazol‐5‐yl)‐indoles
Author(s) -
Wang QingDong,
Yang JinMing,
Zhou Bin,
Fang Dong,
Ren Jiangmeng,
Zeng BuBing
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700612
Subject(s) - regioselectivity , indole test , chemistry , reaction conditions , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis
An efficient Debus‐Radziszewski reaction of C‐3 indole‐substituted 1,2‐diketones with aromatic aldehydes, anilines and NH 4 OAc leading to the preparation of 3‐(1,2,4‐triaryl‐1 H ‐imidazol‐5‐yl)‐indoles was developed. The desired products were obtained with highly regioselectivities under mild conditions.