Premium
FeSO 4 ⋅7H 2 O Catalyzed Rapid and Efficient One‐Pot Multicomponent Synthesis of Functionalized Pyrazol‐yl‐pyrazolone Methanes
Author(s) -
Tabassum Sumaiya,
Govindaraju Santhosh,
Pasha Mohamed Afzal
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700602
Subject(s) - ethyl acetoacetate , pyrazolone , hydrazine (antidepressant) , chemistry , catalysis , hydrazone , one pot synthesis , organic chemistry , combinatorial chemistry , chromatography
An efficient, environmentally benign and inexpensive route to the synthesis of a series of novel substituted pyrazol‐yl‐pyrazolone methanes has been developed via a one‐pot pseudo five‐component cyclocondensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine catalyzed by FeSO 4 ⋅7H 2 O in aqueous medium. The single‐crystal X‐ray diffraction was obtained for two of the derivatives. Our approach, in comparison with other reported methods is noteworthy, as it offers several advantages, such as shorter reaction time, higher yields, mild conditions, is expeditious and clean. We have herein successfully demonstrated a perfect synergy for eco‐compatible organic synthesis.