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Efficient and Controllable Esterification of P(O)‐OH Compounds Using Uronium‐Based Salts
Author(s) -
Xiong Biquan,
Hu Chenghong,
Gu Jingfang,
Yang Changan,
Zhang Panliang,
Liu Yu,
Tang Kewen
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700596
Subject(s) - yield (engineering) , reagent , phenols , chemistry , reaction conditions , broad spectrum , organic chemistry , combinatorial chemistry , catalysis , materials science , metallurgy
An efficient and convenient method is developed for the direct esterification of P(O)‐OH compounds with alcohols under room temperature. The protocol makes use of inexpensive uronium‐based salts as coupling reagents and shows good tolerance towards numerous alcohols, giving the corresponding esterification products in good to excellent yield. Phenols are also tolerated in this reaction. It is a simple way to produce a broad spectrum of functionalized phosphinates, phosphonates, and phosphates from basic P(O)‐OH starting materials.