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Synthesis and Biological Evaluation of Novel Thiomorpholine 1,1‐Dioxide Derived 1,2,3‐Triazole Hybrids as Potential Anticancer Agents
Author(s) -
Battula Kumara Swamy,
Narsimha Sirassu,
Thatipamula Ranjith Kumar,
Reddy Yellu Narsimha,
Nagavelli Vasudeva Reddy
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700524
Subject(s) - chemistry , triazole , combinatorial chemistry , organic chemistry
In this report, we describe the synthesis and biological evaluation of a new series of (4‐((1‐(aryl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)(1,1‐dioxidothiomorpholino)methanone derivatives ( 6 a‐6 n ). All the new derivatives were well analyzed by 1 H NMR, 13 C NMR, FTIR, mass spectral and elemental data. The synthesized compounds were screened for in vitro anticancer activity against three cancer cell lines (MCF‐7, HeLa, and HEK293) and compared with standard drug cisplatin. Three ( 6 b , 6 g and 6 i ) out of fourteen derivatives exhibited potent anticancer activity against MCF‐7, HeLa, and HEK293. Two ( 6 b and 6 g ) potent hybrids were screened for in vivo studies against EAC bearing mice and found to possess potential anticancer activity.