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Cover Picture: (ChemistrySelect 09/2017)
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700513
Subject(s) - analyte , enantiomer , monoclonal antibody , computer science , cover (algebra) , chemistry , chromatography , simple (philosophy) , combinatorial chemistry , information retrieval , antibody , stereochemistry , engineering , medicine , mechanical engineering , immunology , philosophy , epistemology
The cover picture shows how optical isomers can be separated with high enantiopurity. A procedure for chiral separation based on the difference in the molecular weights of the antigen‐antibody complex and analyte is developed. Atroposelective monoclonal antibodies (mAbs) were successfully isolated. Unlike chromatographic methods, the high molecular recognition ability of mAb can separate enantiomers with a one‐step physical event. The large difference in the molecular weights between the analyte and mAbs realizes the separation of the free analyte by ultrafiltration. In addition, both enantiomers can be obtained by a simple one‐step procedure where mAbs are prepared for each enantiomer. More information can be found in the Communication by Adachi et al. (DOI: 10.1002/slct.201700231).