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First Vesicular Self‐Assembly of Crotocembraneic Acid, a Nano‐Sized Fourteen Membered Macrocyclic Diterpenic Acid
Author(s) -
Bag Braja G.,
Barai Abir C.,
Wijesekera Kanchana,
Kittakoop Prasat
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700500
Subject(s) - aqueous solution , solvent , nano , self assembly , chemistry , vesicle , molecule , nanotechnology , organic chemistry , chemical engineering , materials science , membrane , biochemistry , engineering
Study of the spontaneous self‐assembly of molecules in aqueous binary solvent mixture yielding vesicular self‐assemblies has been an area of intense research in recent years because of its tremendous potential application in controlled‐release drug delivery systems, medical implants, tissue engineering, etc. Crotocembraneic acid 1 , a nano‐sized 14‐membered macrocyclic diterpenic acid, is extractable from the leaves of Croton oblongifolius Roxb. First self‐assembly property of the nano‐sized macrocyclic diterpenoid 1 in aqueous binary solvent mixtures is reported here. The diterpenoid spontaneously self‐assembled in aqueous binary solvent mixtures yielding vesicles of nano‐ to micro‐meter diameters. The vesicular self‐assemblies were capable of entrapping various fluorophores including the anticancer drug doxorubicin.