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Photophysical, Electrochemical Studies of Novel Pyrazol‐4‐yl‐2,3‐dihydroquinazolin‐4(1 H )‐ones and Their Anticancer Activity
Author(s) -
Kamble Atulkumar A.,
Kamble Ravindra R.,
Chougala Lakkanna S.,
Kadadevarmath Jagadish S.,
Maidur Shivaraj R.,
Patil Parutagouda S.,
Kumbar Mahadev N.,
Marganakop Sheetal B.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700498
Subject(s) - cyclic voltammetry , electrochemistry , density functional theory , quantum yield , elemental analysis , yield (engineering) , chemistry , fluorescence , proton nmr , nuclear chemistry , absorption (acoustics) , absorption spectroscopy , carbon 13 nmr , spectroscopy , combinatorial chemistry , medicinal chemistry , materials science , computational chemistry , organic chemistry , physics , electrode , quantum mechanics , composite material , metallurgy
A series of novel 2,3‐dihydroquinazolin‐4(1 H )‐ones 7 a‐g were designed, synthesized and were characterized by IR, 1 H & 13 C NMR, MS, and elemental analysis. The optical and electrochemical properties have been studied using UV‐Vis absorption, fluorescence spectroscopy, life time and cyclic voltammetry (CV) measurements. Quantum yield and effect of solvents for the compounds 7 a ‐ g were investigated. Density Functional Theory (DFT) computations have been carried out for all the synthesized compounds and the computed values found to be approximately in close agreement with the experimental results. Further, the compounds 7 a , 7 d , 7 f and 7 g were evaluated for their anticancer activity at National Cancer Institute, NIH, Bethesda, USA and have shown moderate to good anticancer activities.