Premium
Synthesis of 3‐Substituted Quinazolinones via C‐N and C–C bond Cleavage of Enaminone
Author(s) -
Ambethkar Sethurajan,
Kalaiselvi Mariappan,
Padmini Vediappen,
Bhuvanesh Nattamai
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700457
Subject(s) - bond cleavage , cleavage (geology) , chemistry , combinatorial chemistry , stereochemistry , polymer chemistry , organic chemistry , catalysis , materials science , fracture (geology) , composite material
A general and efficient TsOH mediated reaction of o ‐aminobenzamides with enaminone via C−N and C−C bond cleavage leading to quinazolinones has been achieved. This strategy involves C−N/C−C bond cleavage and C−N bond formation in a single operation. Highlight of this work is associated metal free, peroxide free and base free reaction condition. All the synthesized compounds were characterized by NMR and ESI‐MS spectral studies.