5‐Amino‐6,7,8,9‐Tetrahydrobenzo[ b ][1,8]Naphthyridin‐2(1 H )‐One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy | Zendy

Balmori Alba | Zendy; Chioua Mourad | Zendy; de la Bellacasa Raimon Puig | Zendy; EstradaTejedor Roger | Zendy; Ismaili Lhassane | Zendy; MarcoContelles José | Zendy; Borrell José I. | Zendy

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5‐Amino‐6,7,8,9‐Tetrahydrobenzo[ b ][1,8]Naphthyridin‐2(1 H )‐One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy

Author(s) -

Balmori Alba,

Chioua Mourad,

de la Bellacasa Raimon Puig,

EstradaTejedor Roger,

Ismaili Lhassane,

MarcoContelles José,

Borrell José I.

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201700289

Subject(s) - acetylcholinesterase , dihydropyridine , antioxidant , chemistry , stereochemistry , combinatorial chemistry , pharmacology , enzyme , medicine , biochemistry , organic chemistry , calcium

In this communication we have described the synthesis of 2‐amino‐6‐oxo‐1,6‐dihydropyridine‐3‐carbonitrile ( 4 ), and the preparation of 5‐amino‐6,7,8,9‐tetrahydrobenzo[ b ][1,8]naphthyridin‐2(1 H )‐one ( 3 a ), a non‐hepatotoxic, antioxidant agent, showing moderate, but selective human acetylcholinesterase inhibition.

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