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5‐Amino‐6,7,8,9‐Tetrahydrobenzo[ b ][1,8]Naphthyridin‐2(1 H )‐One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy
Author(s) -
Balmori Alba,
Chioua Mourad,
de la Bellacasa Raimon Puig,
EstradaTejedor Roger,
Ismaili Lhassane,
MarcoContelles José,
Borrell José I.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700289
Subject(s) - acetylcholinesterase , dihydropyridine , antioxidant , chemistry , stereochemistry , combinatorial chemistry , pharmacology , enzyme , medicine , biochemistry , organic chemistry , calcium
In this communication we have described the synthesis of 2‐amino‐6‐oxo‐1,6‐dihydropyridine‐3‐carbonitrile ( 4 ), and the preparation of 5‐amino‐6,7,8,9‐tetrahydrobenzo[ b ][1,8]naphthyridin‐2(1 H )‐one ( 3 a ), a non‐hepatotoxic, antioxidant agent, showing moderate, but selective human acetylcholinesterase inhibition.