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Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles
Author(s) -
Wang Tengjiao,
Cho Hyeon Mo,
Lee Myong Euy
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700273
Subject(s) - bicyclic molecule , dimethylsilane , anhydrous , solvent , chemistry , aryl , combinatorial chemistry , inert gas , organic chemistry , alkyl
Abstract A new class of bicyclic silaheterocycles, 6,6‐dimethyl‐2‐aryl‐6,7‐dihydro‐5H‐[1,2,4]triazolo[5,1‐b][1,3,5]thiazasilines, which could be developed as potential sila‐drugs. The reactions of several 3‐aryl‐5‐mercapto‐1,2,4‐triazoles with bis(chloromethyl)dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single‐crystal X‐ray diffraction.